Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation.

@article{Li2008DownregulationO1,
  title={Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation.},
  author={Zenggang Li and Jing Zhao and Yuhong Du and Hae Ryoun Park and Shi-yong R Sun and Leon Bernal-Mizrachi and Alastair Aitken and Fadlo R. Khuri and Haian Fu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 1},
  pages={162-7}
}
The family of 14-3-3 proteins has emerged as critical regulators of diverse cellular responses under both physiological and pathological conditions. Here, we report an important role of 14-3-3zeta in tumorigenesis through a mechanism that involves anoikis resistance. 14-3-3zeta is up-regulated in a number of cancer types, including lung cancer. Through an RNAi approach using human lung adenocarcinoma-derived A549 cells as a model system, we have found that knockdown of a single zeta isoform of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

Similar Papers

Loading similar papers…