Down-regulation by progesterone of CFTR expression in endometrial epithelial cells: a study by competitive RT-PCR.

@article{Mularoni1995DownregulationBP,
  title={Down-regulation by progesterone of CFTR expression in endometrial epithelial cells: a study by competitive RT-PCR.},
  author={A Mularoni and Laurent Beck and Rabia Sadir and G{\'e}rard L. Adessi and M. Nicollier},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={217 3},
  pages={1105-11}
}
To determine the effect of progesterone on the CFTR mRNA level in glandular epithelial cells of guinea-pig endometrium, a competitive RT-PCR was developed using an an internal standard a competitor with the same sequence as CFTR RNA except for a 20 nucleotide insertion. Using this method, the results showed that the CFTR mRNA level decreased in cells treated with estradiol plus progesterone compared to cells receiving estradiol alone. The decrease in CFTR mRNA level was maximal at 12 h… CONTINUE READING

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