Down-regulation Synaptic Vesicle Protein 2A in the Anterior Temporal Neocortex of Patients with Intractable Epilepsy

@article{Feng2009DownregulationSV,
  title={Down-regulation Synaptic Vesicle Protein 2A in the Anterior Temporal Neocortex of Patients with Intractable Epilepsy},
  author={Guibo Feng and Fei Xiao and Yang Lu and Zuchun Huang and Jie Yuan and Zheng Xiao and Zhiqin Xi and Xuefeng Wang},
  journal={Journal of Molecular Neuroscience},
  year={2009},
  volume={39},
  pages={354-359}
}
Synaptic vesicle protein 2A (SV2A) involvement has been reported in the animal models of epilepsy. The aim of this study was to investigate the expression of SV2A in human intractable epilepsy (IE) brain tissue. Using immunohistochemistry, immunofluorescence, and Western blot, we detected SV2A expression in tissue samples from the anterior temporal neocortex of 33 patients who had been surgically treated for IE. We compared these tissues with nine histologically normal anterior temporal lobe… CONTINUE READING

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