Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas.

  title={Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas.},
  author={Suhendan Ekmekcioglu and Julie A. Ellerhorst and Abner M. Mhashilkar and Aysegul A. Sahin and Christopher M. Read and Victor G Prieto and Sunil Chada and Elizabeth Ann Grimm},
  journal={International journal of cancer},
  volume={94 1},
The melanoma differentiation associated gene-7 (mda-7) has a potential inhibitory role in melanoma progression, although the mechanisms underlying this effect are still unknown. mda-7 mRNA has been found to be present at higher levels in cultured normal melanocytes compared with metastatic melanoma cell lines. Furthermore, levels of mda-7 message have shown an inverse correlation with melanoma progression in human tumor samples, suggesting that mda-7 may be a novel tumor suppressor gene. We… CONTINUE READING

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