Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.

@article{Walker2008DownregulatedIA,
  title={Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.},
  author={Nancy M. Walker and Janet E Simpson and Pei-Fen Yen and Ravinder Kaur Gill and Elizabeth V Rigsby and Jennifer M. Brazill and Pradeep K. Dudeja and Clifford W. Schweinfest and Lane L. Clarke},
  journal={Gastroenterology},
  year={2008},
  volume={135 5},
  pages={1645-1653.e3}
}
BACKGROUND & AIMS Electroneutral NaCl absorption across small intestine contributes importantly to systemic fluid balance. Disturbances in this process occur in both obstructive and diarrheal diseases, eg, cystic fibrosis, secretory diarrhea. NaCl absorption involves coupling of Cl(-)/HCO(3)(-) exchanger(s) primarily with Na(+)/H(+) exchanger 3 (Nhe3) at the apical membrane of intestinal epithelia. Identity of the coupling Cl(-)/HCO(3)(-) exchanger(s) was investigated using mice with gene… CONTINUE READING