Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.

@article{Moravckova2012DownregulatedEO,
  title={Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.},
  author={Erika Moravc{\'i}kova and Ev{\vz}en Křepela and Jan Proch{\'a}zka and Ilona Rousalova and Jan {\vC}erm{\'a}k and Kamila Benkov{\'a}},
  journal={International journal of oncology},
  year={2012},
  volume={40 6},
  pages={2111-21}
}
The Apaf-1 interacting protein (APIP) and the uveal autoantigen with coiled coil domains and ankyrin repeats (UACA) belong to endogenous regulators of the apoptosome apparatus, but their role in tumourigenesis and progression of non-small cell lung carcinoma (NSCLC) is not known. Previous studies demonstrated that APIP inhibits the apoptosome-mediated procaspase-9 activation while UACA induces translocation of Apaf-1 from the cytoplasm… CONTINUE READING