Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

@article{OlmosSerrano2016DownSD,
  title={Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination},
  author={Jose Luis Olmos-Serrano and Hyo Jung Kang and William A. Tyler and John C. Silbereis and Feng Cheng and Ying Jie Zhu and Mihovil Pletikos and Lucija Jankovic-Rapan and Nathan Peter Cramer and Zygmunt Galdzicki and Joseph W. Goodliffe and Alan Peters and Claire Sethares and Ivana Delalle and Jeffrey Alan Golden and Tarik F Haydar and Nenad Sestan},
  journal={Neuron},
  year={2016},
  volume={89},
  pages={1208-1222}
}
Trisomy 21, or Down syndrome (DS), is the most common genetic cause of developmental delay and intellectual disability. To gain insight into the underlying molecular and cellular pathogenesis, we conducted a multi-region transcriptome analysis of DS and euploid control brains spanning from mid-fetal development to adulthood. We found genome-wide alterations in the expression of a large number of genes, many of which exhibited temporal and spatial specificity and were associated with distinct… CONTINUE READING
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