Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer.

@article{Hisatake2000DownRegulationOP,
  title={Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer.},
  author={Jun-ichi Hisatake and Takayuki Ikezoe and Mark Carey and Stuart B Holden and Shigeru Tomoyasu and H Phillip Koeffler},
  journal={Cancer research},
  year={2000},
  volume={60 19},
  pages={5494-8}
}
The peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor superfamily. Recent studies found that ligand-activated PPARgamma regulated differentiation and clonal growth of several types of cancer cells, including prostate cancer, suggesting that PPARgamma could be a tumor suppressor. Troglitazone was a widely used… CONTINUE READING