Down-Regulation of miR-126 Is Associated with Colorectal Cancer Cells Proliferation, Migration and Invasion by Targeting IRS-1 via the AKT and ERK1/2 Signaling Pathways

@article{Zhou2013DownRegulationOM,
  title={Down-Regulation of miR-126 Is Associated with Colorectal Cancer Cells Proliferation, Migration and Invasion by Targeting IRS-1 via the AKT and ERK1/2 Signaling Pathways},
  author={Yu Zhou and Xiao Feng and Y. Liu and Shi-cai Ye and H. Wang and Wen-kai Tan and T. Tian and Yu-mei Qiu and H. Luo},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
  • Yu Zhou, Xiao Feng, +6 authors H. Luo
  • Published 2013
  • Biology, Medicine
  • PLoS ONE
  • Background Colorectal carcinoma (CRC) is one of the leading causes of cancer-related mortality worldwide. MicroRNAs (miRNAs, miRs) play important roles in carcinogenesis. MiR-126 has been shown to be down-regulated in CRC. In this study, we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 (IRS-1) and its possible signaling pathway by miR-126. Methods The effect of miR-126 on IRS-1, AKT… CONTINUE READING
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