Down-Regulation of Nogo-B Expression as a Newly Identified Feature of Intrahepatic Cholangiocarcinoma.

@article{Nanashima2016DownRegulationON,
  title={Down-Regulation of Nogo-B Expression as a Newly Identified Feature of Intrahepatic Cholangiocarcinoma.},
  author={Atsushi Nanashima and Go Hatachi and Tetsurou Tominaga and Goushi Murakami and Katsunori Takagi and Junichi Arai and Hideo Wada and Takeshi Nagayasu and Yorihisa Sumida},
  journal={The Tohoku journal of experimental medicine},
  year={2016},
  volume={238 1},
  pages={9-16}
}
Nogo-B, located in the endoplasmic reticulum, is an isoform belonging to the reticulon protein family, which is expressed specifically in cholangiocytes and non-parenchymal cells in the liver. Nogo-B expression is down-regulated with the progression of liver fibrosis, but its distinct function in liver malignancies has not been fully clarified. We have hypothesized that Nogo-B expression may be altered in intrahepatic cholangiocarcinoma (ICC), a relatively rare type of primary liver cancer with… CONTINUE READING
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