Down-Regulation of Inhibitor of Apoptosis Proteins by Deguelin Selectively Induces Apoptosis in Breast Cancer Cells

@article{Peng2007DownRegulationOI,
  title={Down-Regulation of Inhibitor of Apoptosis Proteins by Deguelin Selectively Induces Apoptosis in Breast Cancer Cells},
  author={Xianghong Peng and Prasanthi Karna and Ruth M O'Regan and Xiuju Liu and Rajesh Naithani and Robert M. Moriarty and William Chadwick Wood and Ho-Yyoung Lee and Lily Yang},
  journal={Molecular Pharmacology},
  year={2007},
  volume={71},
  pages={101 - 111}
}
The identification of differentially regulated apoptotic signals in normal and tumor cells allows the development of cancer cell-selective therapies. Increasing evidence shows that the inhibitor of apoptosis (IAP) proteins survivin and XIAP are highly expressed in tumor cells but are absent or have very low levels of expression in normal adult tissues. We found that inhibiting AKT activity with 10 to 100 nM deguelin, a small molecule derived from natural products, markedly reduced the levels of… 
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Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells.
Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway
TLDR
It is shown that the dose-dependent apoptotic inducing effect of Deguelin could be partially reversed by the co-administration of NAC and this effect could translate into a promising therapeutic for lung cancer.
Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis.
TLDR
Deguelin inhibits murine myeloma cell proliferation by inducing apoptosis via regulation of the Bax/Bcl-2 ratio and by inhibition of the activation of Akt.
Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin.
TLDR
The results suggest that survivin expression is induced as an early event in lung carcinogenesis, and deguelin acts as a chemopreventive agent by inducing a reciprocal regulation between AMPK and Akt, resulting in the inhibition of mTOR-mediated survivin.
Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
TLDR
The results indicated that the action of Deguelin on cell migration may be mediated by AKT and ERK mediated signaling pathways, and provide rationale for developing DeguelIn as a chemotherapeutic agent for triple negative breast cancer patients.
Inhibitor of apoptosis proteins and apoptosis.
TLDR
The classification, molecular structures, and properties of IAPs are described and the mechanisms of apoptosis are discussed and the promising significance of clinical applications of I APs in the diagnosis and treatment of malignancy is discussed.
Deguelin Inhibits Growth of Breast Cancer Cells by Modulating the Expression of Key Members of the Wnt Signaling Pathway
TLDR
These studies support the antiproliferative effects of deguelin in human breast cancer cells and, perhaps more importantly, illustrate novel actions by deguel in the Wnt signaling pathway.
Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro
TLDR
Results indicated that deguelin exerted anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro.
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies.
Deguelin Induces Both Apoptosis and Autophagy in Cultured Head and Neck Squamous Cell Carcinoma Cells
TLDR
It is suggested that deguelin may represent a novel and effective chemo-agent against HNSCC, by demonstrating a significant anti-tumor ability and inducing both cell apoptosis and autophagy by modulating multiple signaling pathways in cultured H NSCC cells.
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