Down-Regulated Expression of HSP70 in Correlation with Clinicopathology of Cholangiocarcinoma

  title={Down-Regulated Expression of HSP70 in Correlation with Clinicopathology of Cholangiocarcinoma},
  author={Sirintip Boonjaraspinyo and Thidarut Boonmars and Sasithorn Kaewkes and Porntip Laummaunwai and Somchai Pinlaor and Watchalin Loilome and Puangrat Yongvanit and Zhiliang Wu and Anucha Puapairoj and Vajarabhongsa Bhudhisawasdi},
  journal={Pathology & Oncology Research},
Cholangiocarcinoma is a crucial health problem in northeast Thailand. Although rare, it is a highly fatal disease and the prognosis of CCA patients is very poor. To determine if expression of specific genes is useful for diagnosis and prognosis for CCA. We examined the expression of HSP70, HSP90, RB1, cyclin D1, and HDAC6 in 50 resections of human CCA tissues by quantitative real-time PCR. The expression of HSP70, RB1, and HDAC6 was “dominant down-regulation,” while the expression of cyclin D1… CONTINUE READING
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