Dow Cancer esearch apeutics , Targets , and Chemical Biology Damage Recognition via Activated ATM and p 53 R hway in Nonproliferating Human Prostate Tissue

Abstract

nloaded damage response (DDR) pathways have been extensively studied in cancer cell lines and mouse s, but little is known about how DNA damage is recognized by different cell types in nonmalignant, replicating human tissues. Here, we assess, using ex vivo cultures of human prostate tissue, DDR caused otoxic drugs (camptothecin, doxorubicin, etoposide, and… (More)

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