Doublecortin Interacts with μ Subunits of Clathrin Adaptor Complexes in the Developing Nervous System

@article{Friocourt2001DoublecortinIW,
  title={Doublecortin Interacts with μ Subunits of Clathrin Adaptor Complexes in the Developing Nervous System},
  author={G. Friocourt and P. Chafey and P. Billuart and A. Koulakoff and J. Chelly},
  journal={Molecular and Cellular Neuroscience},
  year={2001},
  volume={18},
  pages={307-319}
}
Doublecortin is a microtubule-associated protein required for normal corticogenesis in the developing brain. We carried out a yeast two-hybrid screen to identify interacting proteins. One of the isolated clones encodes the mu1 subunit of the adaptor complex AP-1 involved in clathrin-dependent protein sorting. We found that Doublecortin also interacts in yeast with mu2 from the AP-2 complex. Mutagenesis and pull-down experiments showed that these interactions were mediated through a tyrosine… Expand
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