Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.

Abstract

The small intestine harbors a substantial number of commensal bacteria and is sporadically invaded by pathogens, but the response to these microorganisms is fundamentally different. We identified a discriminatory sensor by using Toll-like receptor 3 (TLR3). Double-stranded RNA (dsRNA) of one major commensal species, lactic acid bacteria (LAB), triggered… (More)
DOI: 10.1016/j.immuni.2013.02.024

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