Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

@article{Aravin2001DoublestrandedRS,
  title={Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline},
  author={A. A. Aravin and Natalia Naumova and Alexei V. Tulin and Vasilii V. Vagin and Yakov M. Rozovsky and Vladimir A. Gvozdev},
  journal={Current Biology},
  year={2001},
  volume={11},
  pages={1017-1027}
}
BACKGROUND The injection of double-stranded RNA (dsRNA) has been shown to induce a potent sequence-specific inhibition of gene function in diverse invertebrate and vertebrate species. The homology-dependent posttranscriptional gene silencing (PTGS) caused by the introduction of transgenes in plants may be mediated by dsRNA. The analysis of Caenorhabditis elegans mutants impaired with dsRNA-mediated silencing and studies in plants implicate a biological role of dsRNA-mediated silencing as a… CONTINUE READING
Highly Influential
This paper has highly influenced 29 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS