Double-stranded RNA evokes exacerbation in a mouse model of corticosteroid refractory asthma.

@article{Alba2015DoublestrandedRE,
  title={Double-stranded RNA evokes exacerbation in a mouse model of corticosteroid refractory asthma.},
  author={Jorge de Alba and Raquel Otal and Elena Calama and Anna Domenech and Neus Prats and Neil Gozzard and Montserrat Miralpeix},
  journal={Clinical science},
  year={2015},
  volume={129 11},
  pages={973-87}
}
RNA viruses are a major cause of respiratory infections and are known to exacerbate asthma and other respiratory diseases. Our aim was to test the ability of poly(I:C) (polyinosinic:polycytidylic acid), a viral surrogate, to elicit exacerbation in a model of severe asthma driven by HDM (house dust mite) in FCA (Freund's complete adjuvant). Poly(I:C) was… CONTINUE READING