Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells

@article{Dagon2001DoublestrandedRP,
  title={Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells},
  author={Yossi Dagon and Sara Dovrat and Shlomit Vilchik and Dalia Hacohen and Gilat Shlomo and Benjamin Sredni and Samuel Salzberg and Uri Nir},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={8045-8056}
}
The interferon (IFN)-induced, double stranded RNA (dsRNA)-activated serine/threonine kinase, PKR, is a potent negative regulator of cell growth when overexpressed in yeast or mammalian cells. Paradoxically, while it can function as a tumor suppressor and inducer of apoptosis, it is overexpressed in a variety of human cancers. To resolve this enigma, we established cell-lines that overexpress PKR in non-transformed and in v-mos transformed CHO cells. Overexpression of PKR suppressed the… CONTINUE READING