Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells

Abstract

The interferon (IFN)-induced, double stranded RNA (dsRNA)-activated serine/threonine kinase, PKR, is a potent negative regulator of cell growth when overexpressed in yeast or mammalian cells. Paradoxically, while it can function as a tumor suppressor and inducer of apoptosis, it is overexpressed in a variety of human cancers. To resolve this enigma, we… (More)
DOI: 10.1038/sj.onc.1204945

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Cite this paper

@article{Dagon2001DoublestrandedRP, title={Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells}, author={Yossi Dagon and Sara Dovrat and Shlomit Vilchik and Dalia Hacohen and G Ben - Shlomo and Benjamin Sredni and Samuel Salzberg and Uri Nir}, journal={Oncogene}, year={2001}, volume={20}, pages={8045-8056} }