Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.

  title={Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.},
  author={Yongzhan Nie and Graeme L. Hammond and Jinghua Yang},
  journal={Journal of virology},
  volume={81 2},
The RNA-editing enzyme ADAR1 is a double-stranded RNA (dsRNA) binding protein that modifies cellular and viral RNA sequences by adenosine deamination. ADAR1 has been demonstrated to play important roles in embryonic erythropoiesis, viral response, and RNA interference. In human hepatitis virus infection, ADAR1 has been shown to target viral RNA and to suppress viral replication through dsRNA editing. It is not clear whether this antiviral effect of ADAR1 is a common mechanism in response to… CONTINUE READING


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