Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus Ankara.

@article{Ludwig2006DoublestrandedRP,
  title={Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus Ankara.},
  author={Holger Ludwig and Yasemin Suezer and Zoe Waibler and Ulrich Kalinke and Barbara S. Schnierle and Gerd Sutter},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 5},
  pages={1145-55}
}
Infection of human cells with modified vaccinia virus Ankara (MVA) activates the typical cascade-like pattern of viral early-, intermediate- and late-gene expression. In contrast, infection of human HeLa cells with MVA deleted of the E3L gene (MVA-DeltaE3L) results in high-level synthesis of intermediate RNA, but lacks viral late transcription. The viral E3 protein is thought to bind double-stranded RNA (dsRNA) and to act as an inhibitor of dsRNA-activated 2'-5'-oligoadenylate synthetase (2'-5… CONTINUE READING
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