Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G.

@article{Trapp2009DoublestrandedRA,
  title={Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G.},
  author={Susanna Trapp and Nina R Derby and Rachel Singer and Andrew Shaw and Vennansha G. Williams and Stuart G. Turville and Julian W. Bess and Jeffrey D Lifson and Melissa Robbiani},
  journal={Journal of virology},
  year={2009},
  volume={83 2},
  pages={884-95}
}
Human immunodeficiency virus (HIV) is taken up by and replicates in immature dendritic cells (imDCs), which can then transfer virus to T cells, amplifying the infection. Strategies known to boost DC function were tested for their ability to overcome this exploitation when added after HIV exposure. Poly(I:C), but not single-stranded RNA (ssRNA) or a standard DC maturation cocktail, elicited type I interferon (IFN) and interleukin-12 (IL-12) p70 production and the appearance of unique small (15… CONTINUE READING
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