Double-stranded RNA against white spot syndrome virus (WSSV) vp28 or vp26 reduced susceptibility of Litopenaeus vannamei to WSSV, and survivors exhibited decreased susceptibility in subsequent re-infections.

@article{MejaRuz2011DoublestrandedRA,
  title={Double-stranded RNA against white spot syndrome virus (WSSV) vp28 or vp26 reduced susceptibility of Litopenaeus vannamei to WSSV, and survivors exhibited decreased susceptibility in subsequent re-infections.},
  author={Claudio Humberto Mej{\'i}a-Ru{\'i}z and Sergio Vega-Pe{\~n}a and P{\'i}ndaro {\'A}lvarez-Ruiz and C{\'e}sar M Escobedo-Bonilla},
  journal={Journal of invertebrate pathology},
  year={2011},
  volume={107 1},
  pages={
          65-8
        }
}
The antiviral effect of vp28 or vp26 double-stranded (ds) RNA upon single or consecutive white spot syndrome virus (WSSV) intramuscular challenges with a high infectious dose was evaluated. The vp28 dsRNA showed the highest protection both in single (LT(50)=145h at 10d and 98h at 20d post treatment [dpt]) or consecutive (LT(50)=765h) WSSV challenges compared to vp26 dsRNA (LT(50)=126h at 10 d and 57h at 20dpt vs. consecutive challenge LT(50)=751h). Single WSSV challenges showed that animals… CONTINUE READING
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