Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes.

@article{Gray2008DoublestrandedRP,
  title={Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes.},
  author={Jennifer Sue Gray and Hee Kyong Bae and James Chun-bong Li and Allan Sik-yin Lau and James J. Pestka},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={105 2},
  pages={
          322-30
        }
}
Translational inhibitors such as the trichothecene mycotoxin deoxynivalenol (DON) and ribosomal inhibitory proteins (RIPs) induce mitogen-activated protein kinase (MAPK)-driven chemokine and cytokine production by a mechanism known as the ribotoxic stress response (RSR). Double-stranded RNA-activated protein kinase (PKR) associates with the ribosome making it uniquely positioned to sense 28S ribosomal RNA damage and initiate the RSR. We have previously shown that PKR mediates DON-induced MAPK… CONTINUE READING

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