Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18.

@article{Kumar1999DoublestrandedRP,
  title={Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18.},
  author={Kotlo U. Kumar and Sri O. P. Srivastava and Randal J Kaufman},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 2},
  pages={
          1116-25
        }
}
The double-stranded RNA (dsRNA)-activated protein kinase (PKR) provides a fundamental control step in the regulation of protein synthesis initiation through phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha), a process that prevents polypeptide chain initiation. In such a manner, activated PKR inhibits cell growth and induces apoptosis, whereas disruption of normal PKR signaling results in unregulated cell growth. Therefore, tight control of PKR… CONTINUE READING
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