Double-strand breaks may initiate the inversion mutation causing the Hunter syndrome.

@article{Lagerstedt1997DoublestrandBM,
  title={Double-strand breaks may initiate the inversion mutation causing the Hunter syndrome.},
  author={Kristina Lagerstedt and Stanislav L. Karsten and Beth M Carlberg and Wim J. Kleijer and T. Toennesen and U. Pettersson and M L Bondeson},
  journal={Human molecular genetics},
  year={1997},
  volume={6 4},
  pages={627-33}
}
We have previously shown that patients with the Hunter syndrome frequently have suffered from a recombination event between the IDS gene and its putative pseudogene, IDS-2, resulting in an inversion of the intervening DNA. The inversion, which might be the consequence of an intrachromosomal mispairing, is caused by homologous recombination between sequences located in intron 7 of the IDS gene and sequences located distal of exon 3 in IDS-2. In order to gain insight into the mechanisms causing… CONTINUE READING