Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily.

@article{Tsutakawa2012DoubleSB,
  title={Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily.},
  author={Susan E. Tsutakawa and John A. Tainer},
  journal={Mechanisms of ageing and development},
  year={2012},
  volume={133 4},
  pages={195-202}
}
Detailed structural, mutational, and biochemical analyses of human FEN1/DNA complexes have revealed the mechanism for recognition of 5' flaps formed during lagging strand replication and DNA repair. FEN1 processes 5' flaps through a previously unknown, but structurally elegant double-stranded (ds) recognition/single stranded (ss) incision mechanism that both selects for 5' flaps and selects against ss DNA or RNA, intact dsDNA, and 3' flaps. Two major DNA binding interfaces, including a K… CONTINUE READING
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