Double-positive thymocytes select mucosal-associated invariant T cells.

  title={Double-positive thymocytes select mucosal-associated invariant T cells.},
  author={Natalie Seach and Luc{\'i}a Guerri and Lionel le Bourhis and Yvonne Mburu and Yue Cui and St{\'e}phanie Bessoles and Claire Soudais and Olivier Lantz},
  journal={Journal of immunology},
  volume={191 12},
NKT and mucosal-associated invariant T (MAIT) cells express semi-invariant TCR and restriction by nonclassical MHC class Ib molecules. Despite common features, the respective development of NKT and MAIT subsets is distinct. NKTs proliferate extensively and acquire effector properties prior to thymic export. MAIT cells exit the thymus as naive cells and acquire an effector/memory phenotype in a process requiring both commensal flora and B cells. During thymic development, NKTs are selected by… CONTINUE READING


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