Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection.

@article{Nakashima2004DoublePM,
  title={Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection.},
  author={Hisashi Nakashima and Norihiro Furusyo and Norihiko Kubo and Kenichiro Kashiwagi and Yoshitaka Etoh and Seizaburou Kashiwagi and Jun Hayashi},
  journal={Journal of gastroenterology and hepatology},
  year={2004},
  volume={19 5},
  pages={541-50}
}
BACKGROUND AND AIM Hepatitis B virus (HBV) genotype C has a more severe pathogenesis than genotype B in Japan. We retrospectively investigated the relationship between HBV genotype and the core promoter (CP) (nt 1762 and 1764) and precore (PreC) (nt 1896) mutations of the HBV genome. METHODS A total of 129 Japanese patients (42 genotype B and 87 genotype C) with chronic HBV infection, living in two different geographical areas in Japan, were evaluated (mean follow-up period 10.1 +/- 3.8 years… CONTINUE READING