Double placebo design in a prevention trial for Alzheimer's disease.

  title={Double placebo design in a prevention trial for Alzheimer's disease.},
  author={Barbara K. Martin and Curtis L. Meinert and John C. S. Breitner},
  journal={Controlled clinical trials},
  volume={23 1},
The Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) is designed to compare two nonsteroidal anti-inflammatory agents against placebo. A placebo control for two active treatments can be achieved in several ways, each of which may have different implications for the logistics of drug supply, enrollment, adherence to treatment, and the validity of specific treatment comparisons. The authors outline the placebo designs considered in ADAPT, discuss their advantages and disadvantages… CONTINUE READING

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