• Corpus ID: 24996234

Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice.

@article{Bartram2001DoubleoutletRV,
  title={Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice.},
  author={Ulrike Bartram and Dani{\"e}l G M Molin and Lambertus J. Wisse and Azhar Mohamad and L. Philip Sanford and Thomas C. Doetschman and Christian Paul Speer and Robert E. Poelmann and Adriana C. Gittenberger-de Groot},
  journal={Circulation},
  year={2001},
  volume={103 22},
  pages={
          2745-52
        }
}
BACKGROUND Transforming growth factor-beta(2) (TGF-beta(2)) is a member of a family of growth factors with the potential to modify multiple processes. Mice deficient in the TGF-beta(2) gene die around birth and show a variety of defects of different organs, including the heart. METHODS AND RESULTS We studied the hearts of TGF-beta(2)-null mouse embryos from 11.5 to 18.5 days of gestation to analyze the types of defects and determine which processes of cardiac morphogenesis are affected by the… 

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