Double mutant of Aspergillus oryzae for improved production of L-dopa (3,4-dihydroxyphenyl-L-alanine) from L-tyrosine.


Aspergillus oryzae mutant strain UV-7 was further improved for the production of L-dopa from L-tyrosine using chemical mutation. Different putative mutant strains of the organism were tested for the production of L-dopa in triplicate shake-flask cultures. Among these putative mutants, the strain designated SI-12 gave a maximal production of L-dopa (444+/-14… (More)



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