Double minute amplification of mutant PDGF receptor α in a mouse glioma model

Abstract

In primary brain tumors, oncogenes are frequently amplified and maintained on extrachromosomal DNA as double minutes (DM), but the underlying mechanisms remain poorly understood. We have generated a mouse model of malignant glioma based on knock-in of a mutant PDGF receptor α (PDGFRα) that is expressed in oligodendrocyte precursor cells (OPCs) after… (More)
DOI: 10.1038/srep08468
View Slides

Topics

  • Presentations referencing similar topics