Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery.

@article{Gumpert2008DoublemembraneGJ,
  title={Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery.},
  author={Anna M. Gumpert and Joseph S Varco and Susan M Baker and Michelle Piehl and Matthias M Falk},
  journal={FEBS letters},
  year={2008},
  volume={582 19},
  pages={2887-92}
}
Direct cell-cell communication mediated by plasma membrane-spanning gap junction (GJ) channels is vital to all aspects of cellular life. Obviously, GJ intercellular communication (GJIC) requires precise regulation, and it is known that controlled biosynthesis and degradation, and channel opening and closing (gating) are exploited. We discovered that cells internalize GJs in response to various stimuli. Here, we report that GJ internalization is a clathrin-mediated endocytic process that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

The connexin 43 C-terminus: A tail of many tales.

Biochimica et biophysica acta. Biomembranes • 2018
View 1 Excerpt

Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299

Journal of cellular and molecular medicine • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Regulated portals of entry into the cell

View 4 Excerpts
Highly Influenced

Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…