Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery.

  title={Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery.},
  author={Anna M. Gumpert and Joseph S Varco and Susan M Baker and Michelle Piehl and Matthias M Falk},
  journal={FEBS letters},
  volume={582 19},
Direct cell-cell communication mediated by plasma membrane-spanning gap junction (GJ) channels is vital to all aspects of cellular life. Obviously, GJ intercellular communication (GJIC) requires precise regulation, and it is known that controlled biosynthesis and degradation, and channel opening and closing (gating) are exploited. We discovered that cells internalize GJs in response to various stimuli. Here, we report that GJ internalization is a clathrin-mediated endocytic process that… CONTINUE READING


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