Double-layer weekly sustained release transdermal patch containing gestodene and ethinylestradiol.

@article{Gao2009DoublelayerWS,
  title={Double-layer weekly sustained release transdermal patch containing gestodene and ethinylestradiol.},
  author={Yanli Gao and Jinying Liang and Jianping Liu and Yan Xiao},
  journal={International journal of pharmaceutics},
  year={2009},
  volume={377 1-2},
  pages={128-34}
}
The combination therapy of gestodene (GEST) and ethinylestradiol (EE) has shown advanced contraception effect and lower side effect. The present study was designed to develop a weekly sustained release matrix type transdermal patch containing GEST and EE using blends of different polymeric combinations. The multiple-layer technique was adopted in order to maintain a steady permeation flux for 7 days. The effects of polymer types, polymer ratios, permeation enhancers, drug loadings and drug… CONTINUE READING