Double knockout mice reveal a lack of major functional compensation between collagens XV and XVIII.

Abstract

Generation of double knockout mice for collagen types XV and XVIII indicated surprisingly that the mice are viable and do not suffer from any new major defects. Although the two collagens are closely related molecules sharing similarities in tissue expression, we conclude that their biological roles are essentially separate, that of type XV in muscle and type XVIII in the eye. Detailed comparisons of the null mice eyes indicated that type XV collagen seems to be involved in the tunica vasculosa lentis regression process, whereas type XVIII is in the regression of vasa hyaloidea propria, and only minor compensatory effects could be detected. Furthermore, the essential role of type XVIII collagen in the eye is highlighted by the occurrence of this collagen in the epithelial basement membranes of the iris and the ciliary body and in the inner limiting membrane of the retina, sites lacking type XV.

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@article{Ylikrpp2003DoubleKM, title={Double knockout mice reveal a lack of major functional compensation between collagens XV and XVIII.}, author={Ritva Ylik{\"a}rpp{\"a} and Lauri Eklund and Raija T. Sormunen and Anu Muona and Naomi Fukai and Bj{\"{o}rn R Olsen and Taina A Pihlajaniemi}, journal={Matrix biology : journal of the International Society for Matrix Biology}, year={2003}, volume={22 5}, pages={443-8} }