Double knockout Nme1/Nme2 mouse model suggests a critical role for NDP kinases in erythroid development

@article{Postel2009DoubleKN,
  title={Double knockout Nme1/Nme2 mouse model suggests a critical role for NDP kinases in erythroid development},
  author={Edith Horn Postel and Xiaoming Zou and Daniel A. Notterman and Krista M. D. La Perle},
  journal={Molecular and Cellular Biochemistry},
  year={2009},
  volume={329},
  pages={45-50}
}
Nm23/NDP kinases A and B encoded by the Nme1/Nme2 genes are multifunctional enzymes responsible for the majority of NDP kinase activity in mammals. This review summarizes recent studies on their physiological roles using a mouse model in which both Nme1 and Nme2 genes have been deleted. The double knockout mice are stunted in growth and die perinatally. Additionally, these mice display hematologic phenotypes, including severe anemia, abnormal erythroid cell development, loss of the iron… CONTINUE READING