Double isolated limb infusion with cytotoxic agents for recurrent and metastatic limb melanoma.

@article{Lindnr2004DoubleIL,
  title={Double isolated limb infusion with cytotoxic agents for recurrent and metastatic limb melanoma.},
  author={Per Lindn{\'e}r and John F Thompson and Johannes H. W. de Wilt and Marjorie H. Colman and Peter C. A. Kam},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  year={2004},
  volume={30 4},
  pages={
          433-9
        }
}
Metastatic melanoma confined to a limb can be treated effectively by isolated limb infusion (ILI) with cytotoxic drugs. The present study was undertaken to determine whether electively performing a second ILI procedure after 4 weeks increases the frequency and/or duration of response, and also to assess the value of a second ILI when disease recurrence or progression in a limb occurs after a first ILI. In 47 patients, a planned double ILI protocol achieved an overall response (OR) rate of 88… CONTINUE READING
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