Double interfaces binding of two bioactive compounds with a cage-like ferritin.

@article{Meng2020DoubleIB,
  title={Double interfaces binding of two bioactive compounds with a cage-like ferritin.},
  author={Demei Meng and Shengnan Chen and Jie Liu and Qiao'e Wang and Desheng Wang and Mengyao Liu and Zhongkai Zhou and Rui Yang},
  journal={Journal of agricultural and food chemistry},
  year={2020}
}
Ferritin is a cage-like carrier protein with multiple interfaces, allowing the encapsulation and delivery of biologically active molecules. In this study, hesperetin was covalently conjugated to the outer surface of ferritin to fabricate hesperetin-covalently modified ferritin (HFRT) at pH 9.0. This conjugation resulted in a binding equivalent of hesperetin to ferritin of 12.33±0.56 nmol/mg. After covalent binding, the free amino content of HFRT decreased, and the secondary and tertiary… 
8 Citations
Advances in Rational Protein Engineering toward Functional Architectures and Their Applications in Food Science.
TLDR
A comprehensive summary ranging from enzyme manufacturing to cagelike protein nanocarriers engineering and antimicrobial peptides preparation is given, highlighting the importance of rational protein engineering in food biomaterial preparation which could be beneficial for food science.
Tumor-Penetrating Peptide-Functionalized Ferritin Enhances Antitumor Activity of Paclitaxel
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The development of a neuropilin-1 binding peptide (RGERPPR)-ferritin nanocage that specifically targets tumor cells is described.

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