Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform


Due to the increasing throughput of current DNA sequencing instruments, sample multiplexing is necessary for making economical use of available sequencing capacities. A widely used multiplexing strategy for the Illumina Genome Analyzer utilizes sample-specific indexes, which are embedded in one of the library adapters. However, this and similar multiplex… (More)
DOI: 10.1093/nar/gkr771


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