Double-hit B-cell lymphomas.

  title={Double-hit B-cell lymphomas.},
  author={Sietse M Aukema and Reiner Siebert and Ed Schuuring and Gustaaf W. van Imhoff and Hanneke C Kluin-Nelemans and E G Boerma and Philip M. Kluin},
  volume={117 8},
In many B-cell lymphomas, chromosomal translocations are biologic and diagnostic hallmarks of disease. An intriguing subset is formed by the so-called double- hit (DH) lymphomas that are defined by a chromosomal breakpoint affecting the MYC/8q24 locus in combination with another recurrent breakpoint, mainly a t(14;18)(q32;q21) involving BCL2. Recently, these lymphomas have received increased attention, which contributed to the introduction of a novel category of lymphomas in the 2008 WHO… CONTINUE READING
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