Double-edged effect of Vγ9/Vδ2 T lymphocytes on viral expression in an in vitro model of HIV-1/mycobacteria co-infection

@inproceedings{Biswas2003DoubleedgedEO,
  title={Double-edged effect of Vγ9/Vδ2 T lymphocytes on viral expression in an in vitro model of HIV-1/mycobacteria co-infection},
  author={Priscilla Biswas and Marina Ferrarini and Barbara Mantelli and Claudio Fortis and Guido Poli and Adriano Lazzarin and Angelo A. Manfredi},
  year={2003}
}
A reciprocal influence exists between mycobacteria and HIV: HIV-infected individuals are more susceptible to mycobacterial infections and, on the other hand, mycobacterial infection results inacceleration of HIV disease progression. Vγ9/Vδ2 T lymphocytes are known to participate in the defense against intracellular pathogens, including Mycobacterium tuberculosis. Indeed, they kill mycobacteria-infected macrophages and, upon recognition of mycobacterial Ag, release TNF-α and IFN-γ, which are… CONTINUE READING