Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC.

@article{Young2009DoubleDA,
  title={Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC.},
  author={James J. Young and Matthew L. Shapiro},
  journal={Behavioral neuroscience},
  year={2009},
  volume={123 5},
  pages={1028-35}
}
Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal cortex (OFC) influence behavioral flexibility in the rat. The authors tested the effects of PL-IL or OFC infusion with the GABA agonist muscimol in the context of 2 flexible responding tasks: strategy switching and reversal. Muscimol infusion into PL-IL impaired retention of strategy switches but not reversals, whereas muscimol infusion into OFC impaired retention of reversals but not switches. However, whereas training in repeated… CONTINUE READING

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