Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice.

@article{Xu2013DoubleDO,
  title={Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice.},
  author={Pin Xu and Brad A Grueter and Jeremiah K. Britt and Latisha N. McDaniel and Paula J. Huntington and Rachel Hodge and Stephanie Tran and Brittany L. Mason and Charlotte Lee and Linh H Vong and Bradford B. Lowell and Robert C Malenka and Michael Lutter and Andrew A Pieper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 26},
  pages={10759-64}
}
Compulsive behavior is a debilitating clinical feature of many forms of neuropsychiatric disease, including Tourette syndrome, obsessive-compulsive spectrum disorders, eating disorders, and autism. Although several studies link striatal dysfunction to compulsivity, the pathophysiology remains poorly understood. Here, we show that both constitutive and induced genetic deletion of the gene encoding the melanocortin 4 receptor (MC4R), as well as pharmacologic inhibition of MC4R signaling… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 13 times over the past 90 days. VIEW TWEETS