Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.

@article{Takeda2008DoubleDO,
  title={Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.},
  author={Yoshito Takeda and Ping He and Isao Tachibana and Bo Zhou and Kenji Miyado and Hideshi Kaneko and Mayumi Suzuki and Seigo Minami and Takeo Iwasaki and Sho Goya and Takashi Kijima and Toru Kumagai and Mitsuhiro Yoshida and Tadashi Osaki and Toshihisa Komori and Eisuke Mekada and Ichiro Kawase},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 38},
  pages={26089-97}
}
CD9 and CD81 are closely related tetraspanins that regulate cell motility and signaling by facilitating the organization of multimolecular membrane complexes, including integrins. We show that CD9 and CD81 are down-regulated in smoking-related inflammatory response of a macrophage line, RAW264.7. When functions of CD9 and CD81 were ablated with monoclonal antibody treatment, small interfering RNA transfection, or gene knock-out, macrophages were less motile and produced larger amounts of matrix… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-2 of 2 references

Macrophage CD9 and CD81 in COPD-like Phenotype

G. G. Brusselle, K. R. Bracke, +4 authors R. A. Pauwels
Pulm. Pharmacol. Ther • 2006
View 1 Excerpt

Novartis Found

F. Chen, C. Kuang, Y. Chen
2001

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