Double-blind treatment of major depression with dehydroepiandrosterone.

  title={Double-blind treatment of major depression with dehydroepiandrosterone.},
  author={Owen M. Wolkowitz and Victor I. Reus and A Keebler and Natalia Nelson and Mark Friedland and Louann Brizendine and Eve Roberts},
  journal={The American journal of psychiatry},
  volume={156 4},
OBJECTIVE This study was designed to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans. METHOD Twenty-two patients with major depression, either medication-free or on stabilized antidepressant regimens, received either DHEA (maximum dose = 90 mg/day) or placebo for 6 weeks in a double-blind manner and were rated at baseline and at the end of the 6 weeks with the Hamilton Depression Rating Scale. Patients previously stabilized… CONTINUE READING