Double-blind study of leucocyte interferon administration in chronic HBsAg-positive hepatitis.

@article{Weimar1980DoubleblindSO,
  title={Double-blind study of leucocyte interferon administration in chronic HBsAg-positive hepatitis.},
  author={Willem W Weimar and Rudolf Heijtink and Fibo J. W. Ten Kate and Solko W. Schalm and Nathalie Masurel and Huub Schellekens and Kari Cantell},
  journal={Lancet},
  year={1980},
  volume={1 8164},
  pages={336-8}
}
In a double-blind study human leucocyte interferon was given for six weeks to 8 of 16 patients with chronic HBsAg-positive hepatitis. In the first week 12 x 10(6) reference units were administered daily, and thereafter the dose was halved every week. During the first two weeks leucopenia was observed in 6 of the 8 interferon-treated patients. Apart from a drop in DNA-polymerase activity in the first week, no effect was found on indices of hepatitis-B-virus infection. 

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