Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy.

  title={Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy.},
  author={E M Rimmer and Alan Richens},
  volume={1 8370},
Twenty-four patients with frequent drug-resistant seizures took part in a randomised double-blind placebo-controlled crossover trial of the GABA-transaminase inhibitor, gamma-vinyl GABA. It was added to their usual drug treatment in a dose of 3 g daily. The total number of seizures during the 9-week active treatment period was less than that in the placebo period (p less than 0.001, two-way analysis of variance). The greatest effect was on complex partial seizures. Mean weekly seizure frequency… CONTINUE READING


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