Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DNA shows antitumor effect in metastatic melanoma in gray horses.

@article{Mller2011DoubleblindPS,
  title={Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DNA shows antitumor effect in metastatic melanoma in gray horses.},
  author={Jessika- M V M{\"u}ller and Karsten Feige and Patrizia Wunderlin and Andreas F Hoedl and Marina L Meli and Monika Heidemarie Seltenhammer and Paula Grest and Lesley Nicolson and Claude Schelling and Lucie Heinzerling},
  journal={Journal of immunotherapy},
  year={2011},
  volume={34 1},
  pages={58-64}
}
Melanoma is a disease with high incidence in gray horses and has limited therapeutic options in metastatic disease. Gene therapy has shown some success in animal models and human patients. A randomized double-blind, placebo-controlled study was conducted to investigate 2 treatment options using cytokine-encoding plasmid DNA in horses with metastatic melanoma to induce immunologic antitumor effects. Adult gray horses with spontaneously occurring metastatic melanoma (n=26) were included in the… CONTINUE READING

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