Double blind placebo control trial of large neutral amino acids in treatment of PKU: Effect on blood phenylalanine

@article{Matalon2007DoubleBP,
  title={Double blind placebo control trial of large neutral amino acids in treatment of PKU: Effect on blood phenylalanine},
  author={Reuben K Matalon and Kimberlee Michals-Matalon and Gita Bhatia and Alberto Benedetto Burlina and A Burlina and Chiu Yun Yu Braga and Laura Fiori and Marcello Giovannini and Elena Ya Grechanina and P. Yu. Novikov and J. W. Grady and Stephen K Tyring and Flemming Guttler},
  journal={Journal of Inherited Metabolic Disease},
  year={2007},
  volume={30},
  pages={153-158}
}
SummaryLarge neutral amino acids (LNAA) have been used on a limited number of patients with phenylketonuria (PKU) with the purpose of decreasing the influx of phenylalanine (Phe) to the brain. In an open-label study using LNAA, a surprising decline of blood Phe concentration was found in patients with PKU in metabolic treatment centres in Russia, the Ukraine, and the United States. To validate the data obtained from this trial, a short-term double-blind placebo control study was done using LNAA… CONTINUE READING
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