Double-blind parallel comparison of multiple doses of apraclonidine, clonidine, and placebo administered intra-articularly to patients undergoing arthroscopic knee surgery.

@article{Tan2004DoubleblindPC,
  title={Double-blind parallel comparison of multiple doses of apraclonidine, clonidine, and placebo administered intra-articularly to patients undergoing arthroscopic knee surgery.},
  author={Ping-Heng Tan and H. de la Camp B{\"u}rkle and J Cheng and H Shih and Wen-ying Chou and L Yang},
  journal={The Clinical journal of pain},
  year={2004},
  volume={20 4},
  pages={256-60}
}
OBJECTIVE This clinical study assessed and compared the potential analgesic and adverse effect of IA apraclonidine with IA clonidine. METHODS Eighty patients scheduled for arthroscopic knee surgery under general anesthesia were randomized to receive, in a double-blind manner, either IA normal saline (group 1), 50 microg IA apraclonidine (group 2), 150 microg IA apraclonidine (group 3), or 150 microg IA clonidine (group 4), all in a volume of 20 mL subsequent to surgery. Visual analog pain… CONTINUE READING

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